Nutrition

Due to the diversity of nutritional quality and molecular makeup of different foods, diet choices play a significant role in our health. Not only does nutrition deliver energy, but its individual components can act as signaling cues relevant to overall human physiology. In addition, multiple nutrients influence the type and activity of microbes that live within the colon, which in turn has significant effects on the human host.

Microbiome

Humans have evolved to live in symbiosis with microbes – bacteria, archaea, viruses, fungi and protozoa. A large fraction of these microbes are bacteria living within the human gut (the “gut microbiome”). This gut microbiome expresses more than a hundred times the number of genes than are in our human genome and the vast majority of these bacteria are not only good for us, but essential for our health and well being.

Metabolites

The gut bacteria live off the nutrients they receive from the food of their human host and from these nutrients they produce compounds called metabolites. These resulting metabolites (collectively called the “gut metabolome”) can directly influence the behaviour of human cells – in particular immune cells.

Immune System

Efficient immune cell function is needed to keep proliferating cancer cells at bay. Regulation of immune cells with immunotherapy has emerged as one of the most promising approaches to anti-cancer therapy. It is now scientifically recognised that the gut microbiome, likely through the effects of its metabolites on immune cells, plays an important role in increasing the effectiveness and decreasing the toxicity of immunotherapy.

Personalised Cancer Therapy

Given more and more evidence showcases the importance of the nutrition-microbiome-immune system axis, tailoring nutrients and gut bacteria to a person’s metabolic makeup may help us enhance treatment options to fight cancer and other diseases. We believe such new, benign and personalised approaches could significantly augment current cancer therapies and reduce their side effects.

Project positioning

Seerave supports the entire value chain: from biomarker discovery, to translation into diagnostics and therapeutics and ultimately clinical implementation.

Our discovery projects aim at identifying novel biomarkers that are able to predict the effect of nutrition-microbiome modulations on the immune system and cancer.

Biomarkers such as specific bacterial strains or prebiotics can represent the foundation of novel diagnostic and therapeutic approaches. For example, the ability to track a predictive biomarker is of key importance to make more and more personalised approaches possible. These projects are often of preclinical or clinical observational nature and are supervised by leading academic grantees.

Our implementation projects aim at translating novel biomarkers or biological concepts into actionable diagnostic or therapeutic approaches.

These projects entail early feasibility studies aiming at establishing technical and logistical implementation. This can for example be an exploratory clinical trial using a novel treatment approach or trying to establish the technical feasibility of a novel diagnostic tool. These projects are at the intersection of academia and industry and may involve academic grantees, independent service providers as well early-stage startups.

Our ultimate goal is to implement novel diagnostic and therapeutic approaches based on the nutrition-microbiome-immune system axis in cancer patient cohorts.

This will usually happen in combination with existing therapies, trying to enhance their efficacy or reduce side effects. By applying novel diagnostic tools, we strive to accelerate approaches where patients can be stratified according to the likelihood of benefitting from a given therapeutic regimen. Not only will these trials have an immediate impact on patient benefit, but novel insights will accelerate our efforts in the discovery and implementation projects, resulting in a positive feedback loop.

Our discovery projects aim at identifying novel biomarkers that are able to predict the effect of nutrition-microbiome modulations on the immune system and cancer.

Biomarkers such as specific bacterial strains or prebiotics can represent the foundation of novel diagnostic and therapeutic approaches. For example, the ability to track a predictive biomarker is of key importance to make more and more personalised approaches possible. These projects are often of preclinical or clinical observational nature and are supervised by leading academic grantees.

Our implementation projects aim at translating novel biomarkers or biological concepts into actionable diagnostic or therapeutic approaches.

These projects entail early feasibility studies aiming at establishing technical and logistical implementation. This can for example be an exploratory clinical trial using a novel treatment approach or trying to establish the technical feasibility of a novel diagnostic tool. These projects are at the intersection of academia and industry and may involve academic grantees, independent service providers as well early-stage startups.

Our ultimate goal is to implement novel diagnostic and therapeutic approaches based on the nutrition-microbiome-immune system axis in cancer patient cohorts.

This will usually happen in combination with existing therapies, trying to enhance their efficacy or reduce side effects. By applying novel diagnostic tools, we strive to accelerate approaches where patients can be stratified according to the likelihood of benefitting from a given therapeutic regimen. Not only will these trials have an immediate impact on patient benefit, but novel insights will accelerate our efforts in the discovery and implementation projects, resulting in a positive feedback loop.

Principles

Involved

As strong believers in science, Seerave is in close contact with the academic teams and entrepreneurs. We consider ourselves as an active partner of the projects we support and apart from financial means, we like to contribute our own experience and network to accelerate impact.

Pragmatic and proactive

We are committed to deploy resources and strategies appropriate for each individual project - from supporting academics, launching translational projects and partnering with entrepreneurs and other disciplines.

Collaboration and community

We connect an inspiring community with think tanks, roundtables and retreats and facilitate partnerships across disciplines and borders. Institutions working with us nominate a Seerave Fellow who is regularly invited to exchange in dedicated meetings.

Open Science

Seerave encourages their projects to opt for open science principles including data sharing, transparency and accessibility of knowledge.

Holistic

We adopt a circular perspective considering the entire value chain from planetary to human health.

Impact from bench to bedside

Step by step we are aiming for impact

Active since 2017, we are proud of the network we have built, the collaborations we have established and the impact we have generated.

350+

Patients Impacted

10

Scientific Studies

17

Publications

34

Partners, Projects & Collaborations

17

Seerave Fellows

8

Research Institutes

5

Translational Initiatives

5

Impact Investments